World Journal of Advanced Scientific Research 2021-07-29T05:01:01+00:00 Editor in chief - Dr. Jeevan S. Open Journal Systems <p>WJASR is a budding author friendly journal. It intends to promote innovation, new ideas, techniques, provide a platform for budding researchers and clinicians to showcase their work and provide adequate credit to them. It strives to maintain the high standards of quality and authenticity in its published work. It is a open access, interdisciplinary, bimonthly, peer reviewed journal with a focus to encourage research and development.</p> <p>It publishes original research papers, case studies, review papers, literature reviews, book reviews, short communications, technical note from researchers, Applied and educational articles in all areas of research. </p> <p>It welcomes researchers, scholars, scientists, clinicians and students to send in their research work and follows a fast review and publishing process.</p> <p>It publishes research papers, articles and communications in the fields of Medicine, Dentistry, Homeopathy, Ayurveda, Engineering and Nursing.</p> <p>We are happy to inform you that WJASR has successfully moved onto the Open Journal System (OJS) Platform and is now indexed with Google Scholar and Crossref.</p> <p>This enables all WJASR articles to be available on google scholar.</p> <p>Crossref (formerly styled CrossRef) is an official Digital Object Identifier (DOI) Registration Agency of the International DOI Foundation. It is run by the Publishers International Linking Association Inc.</p> <p>A DOI, or Digital Object Identifier, is a string of numbers, letters and symbols used to permanently identify an article or document and link to it on the web. A DOI will help your reader easily locate a document from your citation.</p> <p>WJASR articles can now get a DOI number through Crossref. However this shall be a paid service.</p> <p>Kindly note that DOI is purely an optional service and WJASR remains a free to publish academic online journal.</p> <p>We shall continue to publish articles for free to encourage research and budding authors, however should you require a DOI for your manuscript it shall be a paid service as mentioned above.</p> Early Referral Recommendation For Diagnosis Of Rheumatoid Arthritis 2021-07-05T04:02:45+00:00 Mukhamedaliyevna Tashpulatova Maktuba Mukhamedaliyevna 2021-07-05T00:00:00+00:00 Copyright (c) 2021 Insight To The Disturbances Of Iron Metabolism 2021-07-05T03:26:39+00:00 Nabiyev Abdusamat Utkurovich <p>Iron deficiency, as well as its excess, lead to serious disruption of these<br>processes. Iron deficiency states are the reason for a decrease in working<br>capacity, an increase in susceptibility to viral diseases, especially in children, and cause growth and development retardation. Iron overload and poisoning<br>lead to the activation of processes that can cause cell death. In this regard, timely diagnosis of disorders of iron metabolism and subsequent monitoring of<br>treatment require knowledge of not only pathophysiological mechanisms, but<br>also methodological capabilities and correct interpretation of clinical and<br>biochemical parameters of iron metabolism.</p> 2021-07-05T00:00:00+00:00 Copyright (c) 2021 Modern Aspects Of The Pathogenetic Mechanisms Of The Osteoarthritis 2021-07-05T03:39:53+00:00 Sagatova Dilnoza Rakhimovna <p>Osteoarthritis is an urgent medical and social problem for most<br>countries of the world due to its high prevalence, which reaches about 25% of the<br>population. This disease is most common among women and is one of the causes of<br>reduced work capacity and increased disability. The article discusses the relationship<br>between cytokines and markers of endothelial dysfunction and nonspecific immune<br>reactivity, the main mechanisms of the development of degenerative-dystrophic and<br>inflammatory processes at the microcirculatory level, since microcirculatory<br>imbalance is one of the main mechanisms in joint diseases. The study of cytokine<br>networks and changes in their structure, analysis of correlations between changes in<br>cytokine concentrations relative to each other, as well as in combination with other<br>factors directly actualized in the process of diagnosing and treating a patient, is a<br>promising area of modern medicine. In osteoarthritis, endothelial dysfunction is<br>a component of microcirculatory disorders. Desquamated endothelial cells and<br>vasculoendothelial growth factor are the main indicators of damage to the<br>microvasculature. Under the influence of pro-inflammatory cytokines, homeostasis in<br>the microcirculatory link is destabilized. A necessary element in the diagnosis of<br>osteoarthritis is the detection of an early marker - monocytic chemoattractant protein- 1 (MCP-1)</p> 2021-07-05T00:00:00+00:00 Copyright (c) 2021 Photodynamic Therapy – Coupling Of Light And Dye – A Review 2021-07-29T05:01:01+00:00 Dr. V.R. Balaji, Dr. M. Allan Jeba Seeli, Dr. D. Manikandan <p>The oral cavity is colonized by a large number and highly diversified communities of micro-organisms. Bacterial biofilm present on tooth or root surface is a major cause of gingivitis and periodontitis. Chemical antimicrobial agents are widely used in prophylactic and therapeutic regimens for dental plaque related diseases. As these agents are difficult to maintain at therapeutic concentrations in the oral cavity and can be rendered ineffective by resistance development in target organisms, there is a need for an alternative antimicrobial approach. A novel approach, photodynamic therapy (PDT), could be a solution to these problems. Lethal photosensitization of many bacteria, both Gram positive and Gram negative was found in many studies. The advantage of this new approach includes rapid bacterial elimination, minimal chance of resistance development and safety of adjacent host tissue and normal microflora.</p> 2021-07-28T00:00:00+00:00 Copyright (c) 2021