Modern Aspects Of The Pathogenetic Mechanisms Of The Osteoarthritis


  • Sagatova Dilnoza Rakhimovna


Osteoarthritis, cytokines, monocytic chemoattractant protein, desquamated endothelial cells, vasculoendothelial growth factor


Osteoarthritis is an urgent medical and social problem for most
countries of the world due to its high prevalence, which reaches about 25% of the
population. This disease is most common among women and is one of the causes of
reduced work capacity and increased disability. The article discusses the relationship
between cytokines and markers of endothelial dysfunction and nonspecific immune
reactivity, the main mechanisms of the development of degenerative-dystrophic and
inflammatory processes at the microcirculatory level, since microcirculatory
imbalance is one of the main mechanisms in joint diseases. The study of cytokine
networks and changes in their structure, analysis of correlations between changes in
cytokine concentrations relative to each other, as well as in combination with other
factors directly actualized in the process of diagnosing and treating a patient, is a
promising area of modern medicine. In osteoarthritis, endothelial dysfunction is
a component of microcirculatory disorders. Desquamated endothelial cells and
vasculoendothelial growth factor are the main indicators of damage to the
microvasculature. Under the influence of pro-inflammatory cytokines, homeostasis in
the microcirculatory link is destabilized. A necessary element in the diagnosis of
osteoarthritis is the detection of an early marker - monocytic chemoattractant protein- 1 (MCP-1)




How to Cite

Rakhimovna, S. D. (2021). Modern Aspects Of The Pathogenetic Mechanisms Of The Osteoarthritis. World Journal of Advanced Scientific Research, 4(4), 29-47. Retrieved from